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Postinfectious vasculopathy with evolution to moyamoya syndrome.

Czartoski T, Hallam D, Lacy JM, Chun MR, Becker K

Department of Neurology, University of Washington School of Medicine, Harborview Medical Center, Seattle, WA 98104-249, USA.

BACKGROUND: Parainfectious vascular events are a known complication of bacterial meningitis, typically occurring within two weeks of disease onset. Delayed vascular complications are rare. We present a case of progressive vasculopathy following bacterial meningitis. CASE DESCRIPTION: A 20 year old woman developed progressive vasculopathy after successful treatment of pneumococcal meningitis. Within eight months of her infection, angiography revealed the appearance of moyamoya syndrome. Despite aggressive immunomodulation and anticoagulation, she had multiple strokes. Autopsy confirmed severe narrowing of proximal cerebral vasculature with absence of inflammation or atherosclerosis. CONCLUSIONS: The inflammation and subsequent postinfectious autoimmune response associated with meningitis can lead to a progressive vasculopathy and may represent a pathophysiologic mechanism for the arterial occlusions seen in moyamoya syndrome.

Published 17 January 2005 in J Neurol Neurosurg Psychiatry, 76(2): 256-9.
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