Meningitis Research Today is a free monthly online journal that collates and summarizes the latest research about Meningitis, including details on viral, bacterial, spinal, symptoms, treatment.

Pneumococcal cell wall-induced meningitis impairs adult hippocampal neurogenesis.

Hoffmann O, Mahrhofer C, Rueter N, Freyer D, Bert B, Fink H, Weber JR

Department of Cell Biology, Center for Anatomy, Charité--Universitaetsmedizin Berlin, Schumannstr. 20/21, 10117 Berlin, Germany.

Bacterial meningitis is a major infectious cause of neuronal degeneration in the hippocampus. Neurogenesis, a continuous process in the adult hippocampus, could ameliorate such loss. Yet the high rate of sequelae from meningitis suggests that this repair mechanism is inefficient. Here we used a mouse model of nonreplicative bacterial meningitis to determine the impact of transient intracranial inflammation on adult neurogenesis. Experimental meningitis resulted in a net loss of neurons, diminished volume, and impaired neurogenesis in the dentate gyrus for weeks following recovery from the insult. Inducible nitric oxide synthase (iNOS) immunoreactivity was prominent in microglia in nonproliferating areas of the dentate gyrus and hilus region after meningitis induction. Treatment with the specific iNOS inhibitor N6-(1-iminoethyl)-L-lysine restored neurogenesis in experimental meningitis. These data suggest that local central nervous system inflammation in and of itself suppresses adult neurogenesis by affecting both proliferation and neuronal differentiation. Repair of cognitive dysfunction following meningitis could be improved by intervention to interrupt these actively suppressive effects.

Published 20 August 2007 in Infect Immun, 75(9): 4289-97.
Full-text of this article is available online (may require subscription).

© 2004-2008 Meningitis Research Today. All Rights Reserved.